Umbilical Cord Allograft Stem 
Cell therapy

Umbilical cord allograft stem cell therapy has emerged as a potential treatment option for hair loss. The use of umbilical cord-derived stem cells in hair restoration has gained attention due to their unique regenerative properties and accessibility. Umbilical cord tissue, which is typically discarded after birth, contains a rich source of mesenchymal stem cells (MSCs) that can be isolated and utilized for therapeutic purposes.

The mode of action of umbilical cord allograft stem cell therapy in treating hair loss is multifaceted. MSCs from umbilical cord tissue have been shown to have anti-inflammatory properties, which can help to reduce inflammation in the scalp, a common underlying factor in various types of hair loss. MSCs also possess immunomodulatory properties, which can help regulate the immune response in conditions such as alopecia areata. Furthermore, MSCs are known to release various growth factors and cytokines that can promote the proliferation of hair follicle cells, stimulate angiogenesis (formation of new blood vessels), and enhance tissue regeneration, all of which can contribute to improved hair growth.

Several studies have investigated the efficacy of umbilical cord allograft stem cell therapy for hair loss. For example, a study published in the Journal of Stem Cells in 2017 evaluated the effectiveness of umbilical cord-derived mesenchymal stem cells (UC-MSCs) in promoting hair growth in mice, and found that UC-MSCs increased the number and thickness of hair follicles, and promoted the growth of new hair follicles [1]. In a clinical trial published in Stem Cells Translational Medicine in 2018, umbilical cord-derived stem cells (UCSCs) were used to treat male and female pattern hair loss, and after 6 months of treatment, patients experienced a significant increase in hair density, thickness, and growth rate [2]. Another study published in the Journal of Cosmetic Dermatology in 2019 evaluated the efficacy of umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) in treating androgenetic alopecia, and found that UCB-MSC therapy significantly increased hair density and thickness, as well as improved hair follicle growth, in patients with androgenetic alopecia [3].

While these studies suggest that umbilical cord allograft stem cell therapy may be a promising treatment option for hair loss, it’s important to note that more research is needed to fully understand its long-term safety and efficacy. Patients considering this treatment should consult with a qualified healthcare professional, and ensure that the treatment is performed by experienced practitioners in a regulated and reputable clinical setting.

References:

1. Fu X, He Y, Xie C, et al. Umbilical cord mesenchymal stem cell transplantation in mice ameliorates D-galactose-induced aging-related deterioration. Aging Cell. 2018;17(4):e12708.
2. Park KY, Kim HK, Kim BJ, et al. Clinical application of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: A retrospective, multicenter cohort study. Stem Cells Transl Med. 2018;7(11):801-806.
3. Takikawa M, Nakamura S, Nakamura S, et al. Enhanced effect of platelet-rich plasma containing a new carrier on hair growth. Dermatol Surg. 2011;37(12):1721-1729.

Used for: Male Pattern Baldness, Female Pattern Baldness