Infectious Agents

Infections of the scalp and hair can cause shedding, hair shaft breakage, inflammation and, in severe cases, permanent scarring hair loss. Fungal and bacterial infections are among the most important infectious causes, but other organisms and inflammatory scalp conditions can also affect the hair follicle or produce symptoms that resemble primary hair loss disorders.

Accurate diagnosis matters because conditions that look similar may require completely different treatment. Scaling, redness, pustules, crusting, broken hairs, itching or localized patches of hair loss should not automatically be assumed to represent androgenetic alopecia, alopecia areata or another common form of alopecia.

Some conditions discussed on this page, including seborrheic dermatitis and the presence of Demodex mites, are not conventional contagious infections. They are included because microorganisms can play a role in their biology and because these conditions are frequently encountered when evaluating the scalp and hair.

Tinea Capitis (Scalp Ringworm)

Tinea capitis, commonly called scalp ringworm, is a contagious fungal infection of the scalp and hair caused by fungi known as dermatophytes. Despite the name ringworm, no worm is involved. The condition occurs most commonly in children but can affect people of any age.

Tinea capitis can cause scaling, itching, broken hairs and one or more areas of visible hair loss. Some infected hairs break close to the scalp, producing characteristic black dots. More inflammatory cases can cause tenderness, pustules, crusting or a swollen, boggy inflammatory mass known as a kerion.

A chronic form of tinea capitis known as favus can produce thick yellow crusts around affected hairs and, when severe or longstanding, may result in permanent scarring hair loss.

Species of Trichophyton and Microsporum are among the major fungal causes of tinea capitis worldwide. The organisms responsible can vary by geographic region, population and whether transmission occurs primarily between people or from animals.

Tinea capitis can spread through direct contact with an infected person or animal and through contaminated objects such as combs, brushes, hats, bedding and towels. Because family members or other close contacts can sometimes carry the organism without obvious symptoms, controlling transmission may also be part of treatment.

Diagnosis may involve examination of the scalp and hair, trichoscopy, microscopic examination, fungal culture or other laboratory testing. Identifying the organism can sometimes help guide the choice of treatment.

Because the fungus infects the hair shaft and follicle, tinea capitis generally requires prescription oral antifungal medication. Depending on the organism, age and individual patient, medications such as terbinafine, griseofulvin, itraconazole or fluconazole may be used. Antifungal shampoos can help reduce fungal shedding and transmission but generally are not sufficient as the only treatment.

Early recognition is particularly important when marked inflammation, kerion or favus is present because significant inflammatory damage can permanently injure hair follicles.

Folliculitis

Folliculitis means inflammation of one or more hair follicles. It can occur anywhere hair grows and may appear as small red or pus filled bumps centered around individual follicles. Symptoms can include itching, burning, tenderness or pain.

Many cases are associated with microorganisms. Bacterial folliculitis is commonly caused by Staphylococcus aureus. Pseudomonas bacteria can produce so called hot tub folliculitis after exposure to inadequately maintained pools or hot tubs. Yeasts such as Malassezia and, less commonly, other fungi, viruses or mites can also be associated with follicular inflammation.

Not every case of folliculitis is infectious. Shaving, friction, occlusion, certain medications and inflammatory skin disorders can produce folliculitis or conditions that closely resemble it. Scalp folliculitis therefore should not automatically be treated as a bacterial infection without considering the underlying cause.

Most superficial folliculitis does not cause permanent hair loss. Persistent, deep or severe inflammation involving the scalp can occasionally damage follicles, and some chronic follicular disorders can produce permanent scarring alopecia.

Treatment depends on the cause and severity. Mild cases may resolve with appropriate scalp or skin care, while persistent, recurrent, painful or widespread folliculitis should be medically evaluated. Depending on the diagnosis, treatment may involve antibacterial, antifungal, anti inflammatory or other prescription therapies.

Piedra

Piedra is a superficial fungal infection of the hair shaft characterized by small nodules attached to individual hairs. The name comes from the Spanish word for stone. Two principal forms are recognized: black piedra and white piedra.

Black piedra is caused by the fungus Piedraia hortae and occurs most commonly in tropical climates. It produces firm, dark brown or black nodules that adhere tightly to the hair shaft.

White piedra is most commonly associated with species of Trichosporon and produces softer white, tan or light brown nodules. Depending on the organism and circumstances, piedra can involve scalp, facial or body hair.

Because the infection primarily involves the hair shaft rather than the follicle, piedra usually causes little inflammation or discomfort. Affected hairs can become weakened and break, however, creating the appearance of thinning or hair loss when infection is extensive.

Diagnosis can involve examination of affected hairs, trichoscopy, microscopy and fungal culture. Piedra may sometimes be confused with head lice, hair casts or abnormalities of the hair shaft.

Treatment depends on the type and severity of infection and may include cutting or removing affected hairs together with topical antifungal therapy. Oral antifungal medication may be considered for persistent or extensive cases.

Demodex Folliculorum

Demodex folliculorum is a microscopic mite that normally lives within or near human hair follicles. Demodex mites are extremely common in adults and, in most people, are part of the normal skin environment without causing symptoms or hair loss.

Claims that ordinary Demodex colonization is a major cause of common hair loss or that eliminating these mites will restore hair in people with androgenetic alopecia are not supported by established evidence.

Under unusual circumstances, however, excessive numbers of Demodex mites have been associated with inflammatory skin and follicular disorders. Rare cases of Demodex associated scalp folliculitis have been reported with redness, scaling, pustules and hair loss. This is very different from simply finding Demodex mites on otherwise normal skin.

Treatment directed specifically at Demodex should therefore be based on evidence of a clinically significant condition rather than the presence of mites alone.

Seborrheic Dermatitis

Seborrheic dermatitis is a common chronic inflammatory skin condition that frequently affects the scalp. It is not a contagious infection, although microorganisms that normally live on the skin, particularly Malassezia yeasts, are believed to contribute to the inflammatory response in susceptible individuals.

On the scalp, seborrheic dermatitis commonly causes flaking, scaling, redness and itching and may range from mild dandruff to more significant inflammation. Symptoms frequently fluctuate over time and may worsen during periods of stress, illness, seasonal change or other individual triggers.

Seborrheic dermatitis does not normally destroy hair follicles or cause permanent alopecia. Significant inflammation, scratching or heavy scale may sometimes accompany temporary increased shedding, but persistent or substantial hair loss should prompt consideration of another or additional diagnosis.

Treatment is directed toward controlling yeast activity, scaling and inflammation. Medicated shampoos containing ingredients such as ketoconazole, ciclopirox, selenium sulfide, zinc pyrithione or salicylic acid are commonly used. More significant inflammation may require prescription antifungal, anti inflammatory or other dermatologic treatment.

Because several inflammatory and scarring scalp disorders can initially resemble severe seborrheic dermatitis, persistent redness, pain, burning, pustules, progressive thinning or areas of apparent scarring warrant further medical evaluation.

Syphilitic Alopecia

Syphilitic alopecia is an uncommon form of hair loss associated with secondary syphilis, an infection caused by the bacterium Treponema pallidum. Hair loss may occasionally be one of the first or most noticeable signs of the infection.

The classic presentation consists of irregular areas of non scarring hair loss often described as having a moth eaten appearance. Some patients instead develop diffuse thinning, and others may show a combination of patchy and diffuse loss. Eyebrows, eyelashes, beard hair and other body hair can also be affected.

Because syphilitic alopecia can resemble alopecia areata, tinea capitis, telogen effluvium and other forms of hair loss, the diagnosis may be missed when other signs of secondary syphilis are subtle or absent. Medical history, examination and appropriate blood testing are important when syphilis is a consideration.

Hair follicles are generally not permanently destroyed. With appropriate treatment of the underlying infection, hair growth usually returns over time.

When Scalp Infection Can Cause Permanent Hair Loss

Most infectious conditions affecting the hair and scalp do not permanently destroy hair follicles when they are recognized and treated appropriately. Hair lost through temporary shedding or hair shaft breakage may therefore return once the underlying condition has resolved.

Permanent hair loss becomes a greater concern when infection produces intense or prolonged inflammation deep enough to damage the follicle. Severe inflammatory tinea capitis, kerion, favus, deep or chronic folliculitis and secondary scarring can all place follicles at risk.

Rapidly worsening hair loss accompanied by significant pain, swelling, drainage, extensive crusting, pustules or signs of scarring should therefore be evaluated promptly. The goal is not only to control the infection or inflammation, but also to protect follicles before irreversible damage occurs.

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